| First Author | Deng Z | Year | 2011 |
| Journal | Blood | Volume | 117 |
| Issue | 18 | Pages | 4796-804 |
| PubMed ID | 21403132 | Mgi Jnum | J:173272 |
| Mgi Id | MGI:5013698 | Doi | 10.1182/blood-2010-10-314526 |
| Citation | Deng Z, et al. (2011) Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages. Blood 117(18):4796-804 |
| abstractText | COP9 plays a role in plant innate immunity. The role of COP9 in mammalian innate immune responses is unknown. Here, we show that the COP9 signalosome subunit 5 (CSN5) is required for activation of proinflammatory kinases p38 and Erk and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2. Mice with myeloid-specific CSN5 deficiency have lower mortality in polymicrobial sepsis. CSN5 is required for both Toll-like receptor (TLR) and reactive oxygen species-mediated deneddylation of Cul3, which is essential for Cul3/Keap1-mediated degradation of nuclear factor E2-related factor 2. On the basis of our results COP9 subunit CSN5 is considered to be an essential component of mammalian innate immunity. |
