Primary Identifier | MGI:3775824 | Allele Type | Targeted |
Attribute String | Conditional ready, Null/knockout | Gene | Nras |
Transmission | Germline | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
description | Phenotypic Similarity to Human Syndrome: Primary Melanoma of the CNS (J:198244) in mice homozygous for Nrastm1Tyj and hemizygous for Tg(Tyr-cre)1Lru. |
molecularNote | A loxP site, a puromycin resistance gene cassette and a STOP cassette, and a second loxP site were inserted into intron 1 and a p.G12D activating mutation was introduced in exon 2. The allele will only be expressed after Cre-mediated deletion of the STOP cassette. |