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Allele : Nras<tm1Tyj> neuroblastoma ras oncogene; targeted mutation 1, Tyler Jacks

Primary Identifier  MGI:3775824 Allele Type  Targeted
Attribute String  Conditional ready, Null/knockout Gene  Nras
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
description  Phenotypic Similarity to Human Syndrome: Primary Melanoma of the CNS (J:198244) in mice homozygous for Nrastm1Tyj and hemizygous for Tg(Tyr-cre)1Lru.
molecularNote  A loxP site, a puromycin resistance gene cassette and a STOP cassette, and a second loxP site were inserted into intron 1 and a p.G12D activating mutation was introduced in exon 2. The allele will only be expressed after Cre-mediated deletion of the STOP cassette.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Nras<Loxp-STOP-Loxp (LSL) G12D>,
  • Nras<LSL-G12D>,
  • Nras<LSL-G12D>,
  • Nras<G12D>,
  • Nras<Loxp-STOP-Loxp (LSL) G12D>,
  • Nras<G12D>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

6 Carried By

0 Driven By

47 Publication categories