Primary Identifier | MGI:3776805 | Allele Type | Transgenic |
Attribute String | Constitutively active, Inserted expressed sequence | Gene | Tg(Lck-Stat5b*)1Mafa |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The Lck promoter with the Emu enhancer drives expression of a cDNA encoding a constitutively active Stat5b with point mutations that result in replacement of histidine with arginine at position 299 and serine with phenylalanine at position 711. This mutation results in constitutive phosphorylation of tyrosine 699. |