| First Author | Antal MC | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 48 | Pages | 19822-7 |
| PubMed ID | 23150547 | Mgi Jnum | J:192352 |
| Mgi Id | MGI:5464959 | Doi | 10.1073/pnas.1217668109 |
| Citation | Antal MC, et al. (2012) Estrogen dependent activation function of ERbeta is essential for the sexual behavior of mouse females. Proc Natl Acad Sci U S A 109(48):19822-7 |
| abstractText | We previously generated and characterized a genuine estrogen receptor (ER) beta-null mouse line (named ERbeta(ST)(L-/L-)) and showed that ERbeta(ST)(L-/L-) mice were sterile, due to an ovulation impairment in females and to an unknown reason in males, as their reproductive organs and spermatozoid motility appeared normal. We report here an assessment of the sexual behavior of ERbeta(ST)(L-/L-) null mice. We found that ERbeta(ST)(L-/L-) males display mildly impaired sexual behavior and that ERbeta(ST)(L-/L-) females are significantly less receptive and less attractive than wild-type (WT) females. Decreased attractivity is also exhibited by ERbetaAF2(0) but not by ERbetaAF1(0) mutant females (females devoid of either AF2 or AF1 activation function of ERbeta). Interestingly, by using an odor preference test, we have determined that the low attractiveness of ERbeta(ST)(L-/L-) and ERbetaAF2(0) females is related to a deficiency of a volatile chemosignal. |
