| Primary Identifier | MGI:3776030 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Vhl |
| Transmission | Germline | Strain of Origin | 129S4/SvJae |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A floxed neo cassette was inserted between exon 2 and and exon 3 that contained a nucleotide substitution that results in an amino acid substitution of tryphtophan for arginine at position 166 (R166W). The equivalent mutation in humans, R200W, diminishes binding to and regulation of HIF1A. The neo cassette was removed by germ-line cre-mediated recombination. |
