| First Author | Liang CC | Year | 2018 |
| Journal | Am J Pathol | Volume | 188 |
| Issue | 5 | Pages | 1225-1235 |
| PubMed ID | 29458010 | Mgi Jnum | J:261108 |
| Mgi Id | MGI:6154490 | Doi | 10.1016/j.ajpath.2018.01.017 |
| Citation | Liang CC, et al. (2018) Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis. Am J Pathol 188(5):1225-1235 |
| abstractText | Impairment of the intestinal mucosal immunity significantly increases the risk of acute and chronic diseases. IgA plays a major role in humoral mucosal immunity to provide protection against pathogens and toxins in the gut. Here, we investigated the role of endogenous galectin-9, a tandem repeat-type beta-galactoside-binding protein, in intestinal mucosal immunity. By mucosal immunization of Lgals9(-/-) and littermate control mice, it was found that lack of galectin-9 impaired mucosal antigen-specific IgA response in the gut. Moreover, Lgals9(-/-) mice were more susceptible to developing watery diarrhea and more prone to death in response to high-dose cholera toxin. The results indicate the importance of galectin-9 in modulating intestinal adaptive immunity. Furthermore, bone marrow chimera mice were established, and galectin-9 in hematopoietic cells was found to be critical for adaptive IgA response. In addition, immunized Lgals9(-/-) mice exhibited lower expression of Il17 and fewer T helper 17 (Th17) cells in the lamina propria, implying that the Th17-IgA axis is involved in this mechanism. Taken together, these findings suggest that galectin-9 plays a role in mucosal adaptive immunity through the Th17-IgA axis. By manipulating the expression or activity of galectin-9, intestinal mucosal immune response can be altered and may benefit the development of mucosal vaccination. |
