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Allele : Gt(ROSA)26Sor<tm1(Stat3*A661C*N663C)Sbkv> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sergei B Koralov
Primary Identifier  MGI:3778925 Allele Type  Targeted
Attribute String  Conditional ready, Constitutively active, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  B6.Cg-Thy1<a>
Is Recombinase  false Is Wild Type  false
molecularNote  A targeting construct introduced into the locus a floxed neomycin resistance and STOP cassette, the cDNA for a hyperactive version of human Stat3 (A661C and N663C; STAT3C) with a FLAG-tag, and an FRT-flanked IRES-EGFP reporter cassette. In the presence of Cre recombinase, the STOP element is removed and bicistronic expression of STAT3 and GFP occurs.
  • mutations:
  • Insertion
  • synonyms:
  • Gt(ROSA)26Sor<tm1(STAT3C)Sbkv>,
  • R26Stat3C<stopfl>,
  • Gt(ROSA)26Sor<tm2(STAT3,EGFP)Cgn>,
  • Stat3-C<stoplox>,
  • Gt(ROSA)26Sor<tm1(Stat3*)Sbkv>,
  • Gt(ROSA)26Sor<tm1(STAT3C)Sbkv>,
  • Gt(ROSA)26Sor<tm1(Stat3*)Sbkv>,
  • R26Stat3C<stopfl>,
  • Gt(ROSA)26Sor<tm2(STAT3,EGFP)Cgn>,
  • Stat3-C<stoplox>
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

15 Publication categories





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