| First Author | Sando R 3rd | Year | 2013 |
| Journal | Nat Methods | Volume | 10 |
| Issue | 11 | Pages | 1085-8 |
| PubMed ID | 24056874 | Mgi Jnum | J:201125 |
| Mgi Id | MGI:5511063 | Doi | 10.1038/nmeth.2640 |
| Citation | Sando R 3rd, et al. (2013) Inducible control of gene expression with destabilized Cre. Nat Methods 10(11):1085-8 |
| abstractText | Acute manipulation of gene and protein function in the brain is essential for understanding the mechanisms of nervous system development, plasticity and information processing. Here we describe a technique based on a destabilized Cre recombinase (DD-Cre) whose activity is controlled by the antibiotic trimethoprim (TMP). We show that DD-Cre triggers rapid TMP-dependent recombination of loxP-flanked ('floxed') alleles in mouse neurons in vivo and validate the use of this system for neurobehavioral research. |
