| First Author | Bai L | Year | 2015 |
| Journal | Cell | Volume | 163 |
| Issue | 7 | Pages | 1783-1795 |
| PubMed ID | 26687362 | Mgi Jnum | J:227979 |
| Mgi Id | MGI:5704225 | Doi | 10.1016/j.cell.2015.11.060 |
| Citation | Bai L, et al. (2015) Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking. Cell 163(7):1783-95 |
| abstractText | Touch perception begins with activation of low-threshold mechanoreceptors (LTMRs) in the periphery. LTMR terminals exhibit tremendous morphological heterogeneity that specifies their mechanical receptivity. In a survey of mammalian skin, we found a preponderance of neurofilament-heavy-chain(+) circumferential endings associated with hair follicles, prompting us to develop a genetic strategy to interrogate these neurons. Targeted in vivo recordings revealed them to be Abeta field-LTMRs, identified 50 years ago but largely elusive thereafter. Remarkably, while Abeta field-LTMRs are highly sensitive to gentle stroking of the skin, they are unresponsive to hair deflection, and they encode skin indentation in the noxious range across large, spotty receptive fields. Individual Abeta field-LTMRs form up to 180 circumferential endings, making them the most anatomically expansive LTMR identified to date. Thus, Abeta field-LTMRs are a major mammalian LTMR subtype that forms circumferential endings in hairy skin, and their sensitivity to gentle skin stroking arises through integration across many low-sensitivity circumferential endings. |
