| First Author | Andres AM | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 8 | Pages | 1223-30 |
| PubMed ID | 21439280 | Mgi Jnum | J:171282 |
| Mgi Id | MGI:4949559 | Doi | 10.1016/j.febslet.2011.03.042 |
| Citation | Andres AM, et al. (2011) Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice. FEBS Lett 585(8):1223-30 |
| abstractText | Thioredoxin-interacting protein (Txnip) knockout (TKO) mice exhibit impaired response to fasting. Herein, we showed that activation of adenine monophosphate-activated protein kinase and cellular AMP levels were diminished in the heart and soleus muscle but not in gastrocnemius muscle of fasting TKO mice. Similarly, glycogen content in fasted TKO mice was increased in oxidative muscles but was not different in glycolytic muscles. These data suggest Txnip deficiency has a higher impact on oxidative muscle than glycolytic muscles and provide new insights into the metabolic role of Txnip. |
