| First Author | Mancini G | Year | 2019 |
| Journal | Cell Rep | Volume | 26 |
| Issue | 11 | Pages | 2849-2858.e4 |
| PubMed ID | 30865877 | Mgi Jnum | J:280130 |
| Mgi Id | MGI:6369296 | Doi | 10.1016/j.celrep.2019.02.039 |
| Citation | Mancini G, et al. (2019) Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight. Cell Rep 26(11):2849-2858.e4 |
| abstractText | We found that exposure of adult animals to calorie-dense foods rapidly abolished expression of mitofusin 2 (Mfn2), a gene promoting mitochondrial fusion and mitochondrion-endoplasmic reticulum interactions, in white and brown fat. Mfn2 mRN was also robustly lower in obese human subjects compared with lean controls. Adipocyte-specific knockdown of Mfn2 in adult mice led to increased food intake, adiposity, and impaired glucose metabolism on standard chow as well as on a diet with high calorie content. The body weight and adiposity of mature adipocyte-specific Mfn2 knockout mice on a standard diet were similar to those of control mice on a high-fat diet. The transcriptional profile of the adipose tissue in adipocyte-specific Mfn2 knockout mice was consistent with adipocyte proliferation, increased lipogenesis at the tissue level, and decreased glucose utilization at the systemic level. These observations suggest a possible crucial role for mitochondrial dynamics in adipocytes in initiating systemic metabolic dysregulation. |
