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Allele : Hbb<tm2(HBG1,HBB*)Tow> hemoglobin beta chain complex; targeted mutation 2, Timothy Townes
Primary Identifier  MGI:3790753 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Hbb
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  The major and minor beta chains were replaced with a construct made of a 5.66 kb fragment of the human gamma chain including 1400 bp of 5' flanking sequence and a 4.1 kb fragment of the sickle cell form of human HBB in ES cells already containing a replacement of Hba complex with human HBA, Hbatm1(HBA)Tow. Cre-mediated recombination removed the floxed hygro cassette.
  • mutations:
  • Insertion,
  • Intergenic deletion
  • synonyms:
  • -1400-gamma-beta<S>,
  • Hbb<tm2(HBB*)Tow>,
  • -1400-gamma-beta<S>,
  • Hbb<tm2(HBB*)Tow>,
  • HbSS-Townes,
  • Hbb<hbetas>,
  • HbSS-Townes,
  • Hbb<hbetas>
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1 Feature

Genome

2 Expresses

2 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

1 Driven By

140 Publication categories





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