| First Author | Jeltsch M | Year | 1997 |
| Journal | Science | Volume | 276 |
| Issue | 5317 | Pages | 1423-5 |
| PubMed ID | 9162011 | Mgi Jnum | J:112893 |
| Mgi Id | MGI:3663962 | Doi | 10.1126/science.276.5317.1423 |
| Citation | Jeltsch M, et al. (1997) Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 276(5317):1423-5 |
| abstractText | No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in the skin of transgenic mice resulted in lymphatic, but not vascular, endothelial proliferation and vessel enlargement. Thus, VEGF-C induces selective hyperplasia of the lymphatic vasculature, which is involved in the draining of interstitial fluid and in immune function, inflammation, and tumor metastasis. VEGF-C may play a role in disorders involving the lymphatic system and may be of potential use in therapeutic lymphangiogenesis. |
