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Allele : Egln1<tm1.1Kael> egl-9 family hypoxia-inducible factor 1; targeted mutation 1.1, William G Kaelin

Primary Identifier	MGI:3793288	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Egln1
Transmission	Germline	Strain of Origin	129S6/SvEvTac
Is Recombinase	false	Is Wild Type	false

molecularNote

The floxed exon 2 and 3 of Egln1^tm1Kael were removed via cre-mediated recombination by mating with Tg(EIIa-cre)C5379Lmgd mice. Egln1 mRNA and protein are undetectable in MEFs isolated from E12.5 embryos.

mutations:
Intragenic deletion

cellLines:
Not Specified

synonyms:
PHD2<->,
PHD2<->

earliestPublication:
Minamishima YA, et al. (2008) Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 111(6):3236-44

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

6 Publication categories

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