| First Author | Le Meur M | Year | 1985 |
| Journal | Nature | Volume | 316 |
| Issue | 6023 | Pages | 38-42 |
| PubMed ID | 3925351 | Mgi Jnum | J:111128 |
| Mgi Id | MGI:3653068 | Doi | 10.1038/316038a0 |
| Citation | Le Meur M, et al. (1985) Correcting an immune-response deficiency by creating E alpha gene transgenic mice. Nature 316(6023):38-42 |
| abstractText | We have introduced a cloned Ek alpha gene into embryos of mice incapable of expressing their endogenous E alpha genes. The transcription of Ek alpha was accurate and tissue-specific in the resulting transgenic lines and, in macrophages, Ek alpha transcription could be induced by gamma-interferon. The injected gene conferred on the genetically deficient host strain the ability to mount an immune response to a synthetic polymer. |
