| First Author | Tirotta E | Year | 2013 |
| Journal | J Neuroimmunol | Volume | 254 |
| Issue | 1-2 | Pages | 110-6 |
| PubMed ID | 23102608 | Mgi Jnum | J:286951 |
| Mgi Id | MGI:6403664 | Doi | 10.1016/j.jneuroim.2012.10.005 |
| Citation | Tirotta E, et al. (2013) Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis. J Neuroimmunol 254(1-2):110-6 |
| abstractText | Epstein-Barr virus-induced gene 3 (EBI3) associates with p28 and p35 to form the immunomodulatory cytokines IL-27 and IL-35, respectively. Infection of EBI3-/- mice with the neuroadapted JHM strain of mouse hepatitis virus (JHMV) resulted in increased mortality that was not associated with impaired ability to control viral replication but enhanced T cell and macrophage infiltration into the CNS. IFN-gamma secretion from virus-specific CD4+ and CD8+ T cells isolated from infected EBI3-/- mice was augmented while IL-10 expression muted in comparison to infected WT mice. These data demonstrate a regulatory role for EBI3-associated cytokines in controlling host responses following CNS viral infection. |
