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Publication : Mucolipidosis type IV protein TRPML1-dependent lysosome formation.

First Author  Miller A Year  2015
Journal  Traffic Volume  16
Issue  3 Pages  284-97
PubMed ID  25491304 Mgi Jnum  J:327050
Mgi Id  MGI:6757276 Doi  10.1111/tra.12249
Citation  Miller A, et al. (2015) Mucolipidosis type IV protein TRPML1-dependent lysosome formation. Traffic 16(3):284-97
abstractText  Lysosomes are dynamic organelles that undergo cycles of fusion and fission with themselves and with other organelles. Following fusion with late endosomes to form hybrid organelles, lysosomes are reformed as discrete organelles. This lysosome reformation or formation is a poorly understood process that has not been systematically analyzed and that lacks known regulators. In this study, we quantitatively define the multiple steps of lysosome formation and identify the first regulator of this process.
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