| Primary Identifier | MGI:3795514 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Myh6-Agt)153Tped |
| Strain of Origin | C57BL/6 x BALB/c | Is Recombinase | false |
| Is Wild Type | false |
| description | The transgene construct was injected into either NMRI (two-renin gene strain) or C57BL/6 x BALB/c (one-renin gene strains) mice. A third line was created by crossing transgenic NMRI mice with C57BL/6 animals to generate one-renin gene mice carrying the same transgene number as transgenic NMRI. (J:129140) |
| molecularNote | The transgene is composed of a 1.9-kb rat AGT cDNA coupled to a 5.8-kb mouse alpha-MHC gene promoter. 1.6 kb of the rabbit bIVS2 intronic sequences are also included. RT-PCR analysis indeicated that this transgene was expressed specifically in the heart. Five copies of the transgene are integrated in TG153 transgenic mice. |
