| First Author | Holmstrom SR | Year | 2011 |
| Journal | Genes Dev | Volume | 25 |
| Issue | 16 | Pages | 1674-9 |
| PubMed ID | 21852532 | Mgi Jnum | J:174674 |
| Mgi Id | MGI:5140617 | Doi | 10.1101/gad.16860911 |
| Citation | Holmstrom SR, et al. (2011) LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes Dev 25(16):1674-9 |
| abstractText | We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mitochondrial proteins. LRH-1 cooperates with the pancreas transcription factor 1-L complex (PTF1-L) in regulating exocrine pancreas-specific gene expression. Elimination of LRH-1 in adult mice reduced the concentration of several lipases and proteases in pancreatic fluid and impaired pancreatic fluid secretion in response to cholecystokinin. Thus, LRH-1 is a key regulator of the exocrine pancreas-specific transcriptional network required for the production and secretion of pancreatic fluid. |
