| Primary Identifier | MGI:3797739 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(FXN)YG8Pook |
| Strain of Origin | CBA x C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| description | Line YG22 exhibits slightly greater age-related repeat instability, with a bias toward repeat expansion. |
| molecularNote | The transgenic construct consists of a 370kb YAC insert that includes the entire human FXN gene with GAA triplet repeat sequences, and was injected into fertilized CBA X C57BL/6 hybrid fertilized oocytes. Founder line YG8 was established, carrying 2 tandem copies of the human FXN gene with two GAA trinucleotide repeat sequences of 82 and 190 repeats. This line displayed a transmission rate of 52% to offspring. |
