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Publication : TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

First Author  Michallet MC Year  2008
Journal  Immunity Volume  28
Issue  5 Pages  651-61
PubMed ID  18439848 Mgi Jnum  J:136289
Mgi Id  MGI:3795832 Doi  10.1016/j.immuni.2008.03.013
Citation  Michallet MC, et al. (2008) TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 28(5):651-61
abstractText  Upon detection of viral RNA, the helicases RIG-I and/or MDA5 trigger, via their adaptor Cardif (also known as IPS-1, MAVS, or VISA), the activation of the transcription factors NF-kappaB and IRF3, which collaborate to induce an antiviral type I interferon (IFN) response. FADD and RIP1, known as mediators of death-receptor signaling, are implicated in this antiviral pathway; however, the link between death-receptor and antiviral signaling is not known. Here we showed that TRADD, a crucial adaptor of tumor necrosis factor receptor (TNFRI), was important in RIG-like helicase (RLH)-mediated signal transduction. TRADD is recruited to Cardif and orchestrated complex formation with the E3 ubiquitin ligase TRAF3 and TANK and with FADD and RIP1, leading to the activation of IRF3 and NF-kappaB. Loss of TRADD prevented Cardif-dependent activation of IFN-beta, reduced the production of IFN-beta in response to RNA viruses, and enhanced vesicular stomatitis virus replication. Thus, TRADD is not only an essential component of proinflammatory TNFRI signaling, but is also required for RLH-Cardif-dependent antiviral immune responses.
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