| First Author | Ben Dhaou C | Year | 2022 |
| Journal | Angiogenesis | Volume | 25 |
| Issue | 2 | Pages | 159-179 |
| PubMed ID | 34524600 | Mgi Jnum | J:333756 |
| Mgi Id | MGI:7440141 | Doi | 10.1007/s10456-021-09818-1 |
| Citation | Ben Dhaou C, et al. (2022) Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization. Angiogenesis 25(2):159-179 |
| abstractText | Chemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhibiting the vascularization of tumor grafts. We show here that overexpression of bioactive chemerin in mice results in a reduction of the density of the retinal vascular network during its development and in adults. Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning. This phenotype was reversed to normal in CMKLR1-deficient mice, demonstrating the role of this receptor. Chemerin inhibited also neoangiogenesis in a model of pathological proliferative retinopathy, and in response to hind-limb ischemia. Mechanistically, PTEN and FOXO1 antagonists could almost completely restore the density of the retinal vasculature, suggesting the involvement of the PI3-kinase/AKT pathway in the chemerin-induced vessel regression process. |
