| First Author | Kyburz D | Year | 1993 |
| Journal | Eur J Immunol | Volume | 23 |
| Issue | 8 | Pages | 1956-62 |
| PubMed ID | 8344359 | Mgi Jnum | J:137520 |
| Mgi Id | MGI:3800984 | Doi | 10.1002/eji.1830230834 |
| Citation | Kyburz D, et al. (1993) T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides. Eur J Immunol 23(8):1956-62 |
| abstractText | The fate of in vivo activated CD8+ cytotoxic T cells was studied in transgenic mice expressing a T cell receptor (TCR) specific for the lymphocytic choriomeningitis virus (LCMV) glycoprotein peptide 33-41 presented by major histocompatibility complex (MHC) class I molecules. LCMV infection of TCR transgenic mice induced LCMV-specific effector and memory T cells whereas injection of soluble LCMV glycoprotein peptide 33-41 resulted in tolerance by peripheral deletion and anergy of LCMV-specific T cells after an initial expansion phase. Similarly, LCMV peptide 33-41-specific tolerance could be achieved in normal C57BL/6 mice and was not abrogated by an LCMV infection. These results obtained with a classically MHC-restricted peptide antigen parallel previous findings with retroviral or bacterial superantigens and indicate a possibility to modulate specifically mature peripheral cytotoxic T lymphocytes in vivo. |
