| First Author | Dixon C | Year | 2013 |
| Journal | Cell Mol Neurobiol | Volume | 33 |
| Issue | 7 | Pages | 867-73 |
| PubMed ID | 23852417 | Mgi Jnum | J:321208 |
| Mgi Id | MGI:6877495 | Doi | 10.1007/s10571-013-9961-4 |
| Citation | Dixon C, et al. (2013) Nuclear factor one X regulates Bobby sox during development of the mouse forebrain. Cell Mol Neurobiol 33(7):867-73 |
| abstractText | The transcription factor nuclear factor one X (NFIX) plays a central role during the development of the neocortex and hippocampus, through the activation of astrocyte-specific gene expression and the repression of progenitor-specific pathways. However, our understanding of transcriptional targets of NFIX during cortical development remains limited. Here, we identify the transcription factor Bobby sox (Bbx) as a target for NFI-mediated transcriptional control. BBX is expressed within ventricular zone progenitor cells within the developing neocortex and hippocampus, and its expression is upregulated in Nfix (-/-) mice. Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain. |
