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Allele : Psap<tm2Ggb> prosaposin; targeted mutation 2, Gregory A Grabowski

Primary Identifier  MGI:3802531 Allele Type  Targeted
Attribute String  Not Specified Gene  Psap
Transmission  Germline Strain of Origin  129S/SvEv
Is Recombinase  false Is Wild Type  false
molecularNote  A nucleotide substitution resulting in the amino-acid substitution of the fourth cysteine to phenylalanine in exon 7 was knocked into the open reading frame along with a floxed neo cassette that was subsequently removed by germ line, cre-mediated recombination. The absence of saposin B was confirmed by western blot analysis on liver extracts but the expression of saposin A, C and D (the other forms post-translationally generated from this locus) was not affected.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Psap<B->,
  • Psap<B->,
  • sapB<C240F>,
  • sapB<C240F>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories