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Allele : Tg(H2-L-IL6)46Kish transgene insertion 46, Tadamitsu Kishimoto

Primary Identifier  MGI:3806463 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(H2-L-IL6)46Kish
Strain of Origin  C57BL/6 Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene construct contained 1.4 Kb of the H2-Ld promoter driving expression of the human IL6 cDNA which had a 340 bp 3' untranlated region deleted, to increase mRNA stability. A 770 bp fragment of this construct was inserted into the rabbit beta-globin sequence, resulting in a 3.3 kb fragment which was injected into fertilized C57BL/6 eggs.
  • mutations:
  • Insertion
  • synonyms:
  • H2/huIL-6,
  • L<d>46,
  • H2/huIL-6,
  • L<d>-IL-6,
  • L<d>46,
  • L<d>-IL-6
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

9 Publication categories