Primary Identifier | MGI:3807480 | Allele Type | Targeted |
Attribute String | Modified isoform(s) | Gene | Als2 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A neo cassette replaced exon 2 and part of exon 3 via homologous recombination. Immunoblot blot analysis confirmed the absence of full length protein in brains from homozygous mice. However, immunoblot and RT-PCR analysis detect the presence of other Als2 isoforms in neurons. |