| First Author | Ramos-Prats A | Year | 2022 |
| Journal | Cell Rep | Volume | 39 |
| Issue | 9 | Pages | 110893 |
| PubMed ID | 35649348 | Mgi Jnum | J:358557 |
| Mgi Id | MGI:7311492 | Doi | 10.1016/j.celrep.2022.110893 |
| Citation | Ramos-Prats A, et al. (2022) VIP-expressing interneurons in the anterior insular cortex contribute to sensory processing to regulate adaptive behavior. Cell Rep 39(9):110893 |
| abstractText | Adaptive behavior critically depends on the detection of behaviorally relevant stimuli. The anterior insular cortex (aIC) has long been proposed as a key player in the representation and integration of sensory stimuli, and implicated in a wide variety of cognitive and emotional functions. However, to date, little is known about the contribution of aIC interneurons to sensory processing. By using a combination of whole-brain connectivity tracing, imaging of neural calcium dynamics, and optogenetic modulation in freely moving mice across different experimental paradigms, such as fear conditioning and social preference, we describe here a role for aIC vasoactive intestinal polypeptide-expressing (VIP+) interneurons in mediating adaptive behaviors. Our findings enlighten the contribution of aIC VIP+ interneurons to sensory processing, showing that they are anatomically connected to a wide range of sensory-related brain areas and critically respond to behaviorally relevant stimuli independent of task and modality. |
