| First Author | Ding J | Year | 2021 |
| Journal | Elife | Volume | 10 |
| PubMed ID | 34096504 | Mgi Jnum | J:327570 |
| Mgi Id | MGI:6727647 | Doi | 10.7554/eLife.68181 |
| Citation | Ding J, et al. (2021) Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit. Elife 10:e68181 |
| abstractText | Spatially distributed excitation and inhibition collectively shape a visual neuron's receptive field (RF) properties. In the direction-selective circuit of the mammalian retina, the role of strong null-direction inhibition of On-Off direction-selective ganglion cells (On-Off DSGCs) on their direction selectivity is well-studied. However, how excitatory inputs influence the On-Off DSGC's visual response is underexplored. Here, we report that On-Off DSGCs have a spatially displaced glutamatergic receptive field along their horizontal preferred-null motion axes. This displaced receptive field contributes to DSGC null-direction spiking during interrupted motion trajectories. Theoretical analyses indicate that population responses during interrupted motion may help populations of On-Off DSGCs signal the spatial location of moving objects in complex, naturalistic visual environments. Our study highlights that the direction-selective circuit exploits separate sets of mechanisms under different stimulus conditions, and these mechanisms may help encode multiple visual features. |
