| First Author | Liu Q | Year | 2015 |
| Journal | Nat Med | Volume | 21 |
| Issue | 8 | Pages | 866-8 |
| PubMed ID | 26168292 | Mgi Jnum | J:228761 |
| Mgi Id | MGI:5708800 | Doi | 10.1038/nm.3888 |
| Citation | Liu Q, et al. (2015) c-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair. Nat Med 21(8):866-8 |
| abstractText | Unraveling the fate specification of resident stem cells during lung regeneration is of clinical importance. It has been reported that c-kit(+) progenitor cells resident in the human lung regenerate epithelial lineages upon transplantation into injured mouse lung. Here we test the lineage potential of c-kit(+) cells by inducible genetic lineage tracing. We find that c-kit(+) cells do not contribute to lung epithelium during homeostasis and repair, and instead maintain a vascular endothelial cell fate. These findings call attention to the clinical application of c-kit(+) stem cells as lung epithelial progenitors for the treatment of pulmonary disease. |
