| First Author | Garcia-Junco-Clemente P | Year | 2017 |
| Journal | Nat Neurosci | Volume | 20 |
| Issue | 3 | Pages | 389-392 |
| PubMed ID | 28114295 | Mgi Jnum | J:271925 |
| Mgi Id | MGI:6282769 | Doi | 10.1038/nn.4483 |
| Citation | Garcia-Junco-Clemente P, et al. (2017) An inhibitory pull-push circuit in frontal cortex. Nat Neurosci 20(3):389-392 |
| abstractText | Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input. |
