| First Author | Zhang H | Year | 2024 |
| Journal | Elife | Volume | 13 |
| PubMed ID | 38470102 | Mgi Jnum | J:359975 |
| Mgi Id | MGI:7797275 | Doi | 10.7554/eLife.93151 |
| Citation | Zhang H, et al. (2024) Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion. Elife 13 |
| abstractText | Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence of a distinct subpopulation of Ucp1(-)&Cidea(+) adipocytes that arises from brown-to-white conversion during postnatal life in the periureter region of mouse PRAT. Cold exposure restores Ucp1 expression and a thermogenic phenotype in this subpopulation. These cells have a transcriptome that is distinct from subcutaneous beige adipocytes and may represent a unique type of cold-recruitable adipocytes. These results pave the way for studies of PRAT physiology and mechanisms controlling the plasticity of brown/white adipocyte phenotypes. |
