| First Author | Refaeli R | Year | 2024 |
| Journal | Cell Rep | Volume | 43 |
| Issue | 3 | Pages | 113943 |
| PubMed ID | 38483907 | Mgi Jnum | J:347020 |
| Mgi Id | MGI:7616023 | Doi | 10.1016/j.celrep.2024.113943 |
| Citation | Refaeli R, et al. (2024) Astrocytes control recent and remote memory strength by affecting the recruitment of the CA1-->ACC projection to engrams. Cell Rep 43(3):113943 |
| abstractText | The maturation of engrams from recent to remote time points involves the recruitment of CA1 neurons projecting to the anterior cingulate cortex (CA1-->ACC). Modifications of G-protein-coupled receptor pathways in CA1 astrocytes affect recent and remote recall in seemingly contradictory ways. To address this inconsistency, we manipulated these pathways in astrocytes during memory acquisition and tagged c-Fos-positive engram cells and CA1-->ACC cells during recent and remote recall. The behavioral results were coupled with changes in the recruitment of CA1-->ACC projection cells to the engram: Gq pathway activation in astrocytes caused enhancement of recent recall alone and was accompanied by earlier recruitment of CA1-->ACC projecting cells to the engram. In contrast, Gi pathway activation in astrocytes resulted in the impairment of only remote recall, and CA1-->ACC projecting cells were not recruited during remote memory. Finally, we provide a simple working model, hypothesizing that Gq and Gi pathway activation affect memory differently, by modulating the same mechanism: CA1-->ACC projection. |
