| First Author | Weglage M | Year | 2021 |
| Journal | Cell Rep | Volume | 36 |
| Issue | 4 | Pages | 109437 |
| PubMed ID | 34320355 | Mgi Jnum | J:327009 |
| Mgi Id | MGI:6876822 | Doi | 10.1016/j.celrep.2021.109437 |
| Citation | Weglage M, et al. (2021) Complete representation of action space and value in all dorsal striatal pathways. Cell Rep 36(4):109437 |
| abstractText | The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-specific calcium imaging to determine the activity of striatal projection neurons (SPNs) during motor and decision behaviors in the three major outputs of the dorsomedial striatum: Oprm1(+) striosome versus D1(+) direct and A2A(+) indirect pathway SPNs. We find that Oprm1(+) SPNs show complex tunings to simple movements and value-guided actions, which are conserved across many sessions in a single task but remap between contexts. During decision making, the SPN tuning profiles form a complete representation in which sequential SPN activity jointly encodes task progress and value. We propose that the three major output pathways in the dorsomedial striatum share a similarly complete representation of the entire action space, including task- and phase-specific signals of action value and choice. |
