| First Author | Wang C | Year | 2017 |
| Journal | Cell Rep | Volume | 18 |
| Issue | 12 | Pages | 2825-2835 |
| PubMed ID | 28329676 | Mgi Jnum | J:251065 |
| Mgi Id | MGI:6103189 | Doi | 10.1016/j.celrep.2017.02.071 |
| Citation | Wang C, et al. (2017) Lineage-Biased Stem Cells Maintain Estrogen-Receptor-Positive and -Negative Mouse Mammary Luminal Lineages. Cell Rep 18(12):2825-2835 |
| abstractText | Delineating the mammary differentiation hierarchy is important for the study of mammary gland development and tumorigenesis. Mammary luminal cells are considered a major origin of human breast cancers. However, how estrogen-receptor-positive (ER(+)) and ER(-) luminal cells are developed and maintained remains poorly understood. The prevailing model suggests that a common stem/progenitor cell generates both cell types. Through genetic lineage tracing in mice, we find that SOX9-expressing cells specifically contribute to the development and maintenance of ER(-) luminal cells and, to a lesser degree, basal cells. In parallel, PROM1-expressing cells give rise only to ER(+) luminal cells. Both SOX9(+) and PROM1(+) cells specifically sustain their respective lineages even after pregnancy-caused tissue remodeling or serial transplantation, demonstrating characteristic properties of long-term repopulating stem cells. Thus, our data reveal that mouse mammary ER(+) and ER(-) luminal cells are two independent lineages that are maintained by distinct stem cells, providing a revised mammary epithelial cell hierarchy. |
