| First Author | Zhuang J | Year | 2021 |
| Journal | Cell Rep | Volume | 37 |
| Issue | 2 | Pages | 109826 |
| PubMed ID | 34644562 | Mgi Jnum | J:328366 |
| Mgi Id | MGI:6883793 | Doi | 10.1016/j.celrep.2021.109826 |
| Citation | Zhuang J, et al. (2021) Laminar distribution and arbor density of two functional classes of thalamic inputs to primary visual cortex. Cell Rep 37(2):109826 |
| abstractText | Motion/direction-sensitive and location-sensitive neurons are the two major functional types in mouse visual thalamus that project to the primary visual cortex (V1). It is under debate whether motion/direction-sensitive inputs preferentially target the superficial layers in V1, as opposed to the location-sensitive inputs, which preferentially target the middle layers. Here, by using calcium imaging to measure the activity of motion/direction-sensitive and location-sensitive axons in V1, we find evidence against these cell-type-specific laminar biases at the population level. Furthermore, using an approach to reconstruct axon arbors with identified in vivo response types, we show that, at the single-axon level, the motion/direction-sensitive axons project more densely to the middle layers than the location-sensitive axons. Overall, our results demonstrate that motion/direction-sensitive thalamic neurons project extensively to the middle layers of V1 at both the population and single-cell levels, providing further insight into the organization of thalamocortical projection in the mouse visual system. |
