| First Author | Cembrowski MS | Year | 2018 |
| Journal | Cell | Volume | 173 |
| Issue | 5 | Pages | 1280-1292.e18 |
| PubMed ID | 29681453 | Mgi Jnum | J:263256 |
| Mgi Id | MGI:6160663 | Doi | 10.1016/j.cell.2018.03.031 |
| Citation | Cembrowski MS, et al. (2018) Dissociable Structural and Functional Hippocampal Outputs via Distinct Subiculum Cell Classes. Cell 173(5):1280-1292.e18 |
| abstractText | The mammalian hippocampus, comprised of serially connected subfields, participates in diverse behavioral and cognitive functions. It has been postulated that parallel circuitry embedded within hippocampal subfields may underlie such functional diversity. We sought to identify, delineate, and manipulate this putatively parallel architecture in the dorsal subiculum, the primary output subfield of the dorsal hippocampus. Population and single-cell RNA-seq revealed that the subiculum can be divided into two spatially adjacent subregions associated with prominent differences in pyramidal cell gene expression. Pyramidal cells occupying these two regions differed in their long-range inputs, local wiring, projection targets, and electrophysiological properties. Leveraging gene-expression differences across these regions, we use genetically restricted neuronal silencing to show that these regions differentially contribute to spatial working memory. This work provides a coherent molecular-, cellular-, circuit-, and behavioral-level demonstration that the hippocampus embeds structurally and functionally dissociable streams within its serial architecture. |
