| First Author | Ren X | Year | 2017 |
| Journal | FASEB J | Volume | 31 |
| Issue | 2 | Pages | 711-718 |
| PubMed ID | 27871061 | Mgi Jnum | J:268077 |
| Mgi Id | MGI:6267963 | Doi | 10.1096/fj.201600840R |
| Citation | Ren X, et al. (2017) A small-molecule inhibitor of NF-kappaB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury. FASEB J 31(2):711-718 |
| abstractText | Potent and selective chemical probes are valuable tools for discovery of novel treatments for human diseases. NF-kappaB-inducing kinase (NIK) is a key trigger in the development of liver injury and fibrosis. Whether inhibition of NIK activity by chemical probes ameliorates liver inflammation and injury is largely unknown. In this study, a small-molecule inhibitor of NIK, B022, was found to be a potent and selective chemical probe for liver inflammation and injury. B022 inhibited the NIK signaling pathway, including NIK-induced p100-to-p52 processing and inflammatory gene expression, both in vitro and in vivo Furthermore, in vivo administration of B022 protected against not only NIK but also CCl4-induced liver inflammation and injury. Our data suggest that inhibition of NIK is a novel strategy for treatment of liver inflammation, oxidative stress, and injury.-Ren, X., Li, X., Jia, L., Chen, D., Hou, H., Rui, L., Zhao, Y., Chen, Z. A small-molecule inhibitor of NF-kappaB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury. |
