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Allele : Igh-J<tm3(3H9-VDJ*)Mwg> immunoglobulin heavy chain, joining region; targeted mutation 3, Martin Weigert

Primary Identifier  MGI:3808989 Allele Type  Targeted
Gene  Igh-J Transmission  Germline
Strain of Origin  129P2/OlaHsd Is Recombinase  false
Is Wild Type  false
molecularNote  The endogenous DQ52 and all four heavy chain J elements were replaced by a rearranged heavy chain V 3H9 gene encoding an H chain of anti-dsDNA antibody with two amin acid substitutions. These substitutions were an arginine for an aspartate at position 56 (A56R) and an arginine for a serine at position 76 (S76R). A neomycin resistance gene was also included upstream of the construct.
  • mutations:
  • Intergenic deletion,
  • Insertion
  • synonyms:
  • 3H9H/56R/76R,
  • 3H9H/56R/76R
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories