| First Author | Chesebro B | Year | 1979 |
| Journal | Proc Natl Acad Sci U S A | Volume | 76 |
| Issue | 1 | Pages | 425-9 |
| PubMed ID | 284359 | Mgi Jnum | J:6107 |
| Mgi Id | MGI:54584 | Doi | 10.1073/pnas.76.1.425 |
| Citation | Chesebro B, et al. (1979) Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci U S A 76(1):425-9 |
| abstractText | The dominant C57BL/10 allele of a single autosomal, non-H-2 gene (Rfv-3) was found to be required for recovery from viremia and leukemia induced by Friend virus complex in H-2b/b mice. In H-2a/a mice, the Rfv-3 gene apparently influenced recovery from viremia in the presence of persistent leukemia because these mice lacked the appropriate H-2 genotype for recovery from leukemia. The Rfv-3 gene was distinct from the Fv-2 gene because recovery from viremia was seen in recombinant-inbred mice with the Fv-2s/s genotype. Furthermore, backcross studies indicated that Rfv-3 and Fv-2 were not linked. The Rfv-3 gene may act by influencing the specific anti-FV humoral antibody response. |
