Primary Identifier | MGI:3810080 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Tradd |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A floxed and FRT flanked neo cassette was inserted in intron 2 and a third loxP site was inserted 3' of exon 5. Mice carring this floxed allele were then crossed to mice carrying Tg(EIIa-cre)C5379Lmgd to excise exons 3-5 which code for amino acid residues 51-310. This results in the deletion of the interactin domains for TRAF2 and RIP (receptor interacting domain). |