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Allele : Gpx4<tm2.1Marc> glutathione peroxidase 4; targeted mutation 2.1

Primary Identifier	MGI:3810784	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Gpx4
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

Mice carrying the Gpx4^tm2Marc allele were crossed with mice carrying the Tg(Camk2a-cre)2Gsc transgene to remove exons 5-7 from the germline. Deletion of the exons was confirmed by Southern blotting.

mutations:
Intragenic deletion

cellLines:
Not Specified

earliestPublication:
Seiler A, et al. (2008) Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab 8(3):237-48

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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