| Primary Identifier | MGI:3811335 | Allele Type | Chemically induced (ENU) |
| Gene | Tlr7 | Inheritance Mode | Recessive |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This mutation was discovered in a toll-like receptor (TLR) signaling screen of the G3 progeny of an ENU mutagenized male mouse. It has been identified as an A to T transversion at nucleotide position 732 (Genbank: NM_133211), in the third and final exon, that results in the replacement of a highly conserved asparagine by tyrosine at amino acid position 182 of the protein (N182Y), in the fifth leucine rich repeat (LRR) of the receptor's ectodomain. |
