| First Author | Okamoto M | Year | 1992 |
| Journal | J Exp Med | Volume | 175 |
| Issue | 1 | Pages | 71-9 |
| PubMed ID | 1730928 | Mgi Jnum | J:139864 |
| Mgi Id | MGI:3810252 | Doi | 10.1084/jem.175.1.71 |
| Citation | Okamoto M, et al. (1992) A transgenic model of autoimmune hemolytic anemia. J Exp Med 175(1):71-9 |
| abstractText | We made double transgenic mice bearing immunoglobulin heavy and light chain genes encoding an autoantibody against the mouse erythrocyte by the cross of C57BL/6 mice carrying the transgene for each chain of the immunoglobulin. Although no obvious disorders were found in the single-chain transgenic mice, severely anemic symptoms were found in some of the double transgenic mice, in which most B cells express, at least on their surface, the autoantibody reactive to self-antigens on the erythrocyte. Individual double-transgenic mice showed a wide variation of phenotypes between severe anemia and no symptoms. Both deletion and anergy of autoreactive B cells were seen in each individual mouse, but their relative contribution to self-tolerance was variable and not directly related to the severity of anemia or the amount of the autoantibody produced. This transgenic system provides a good autoimmune disease model for exploring its onset mechanism, and means of its treatment and prevention. |
