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Allele : Tg(Thy1-MAPT*)1Avil transgene insertion 1, J Avila

Primary Identifier  MGI:3813500 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Thy1-MAPT*)1Avil
Strain of Origin  C57BL/6 x CBA Is Recombinase  false
Is Wild Type  false
molecularNote  The promoter was used to drive neuron-specific expression of human MAPT with three point mutations that result in the following amino acid changes: G272V, P301L and R406W. These mutations have been identified in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).
  • mutations:
  • Insertion
  • synonyms:
  • FTDP-17 human tau,
  • FTDP-17 human tau,
  • tau<VLW>,
  • tau<VLW>
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

17 Publication categories