Primary Identifier | MGI:3813500 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Thy1-MAPT*)1Avil |
Strain of Origin | C57BL/6 x CBA | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The promoter was used to drive neuron-specific expression of human MAPT with three point mutations that result in the following amino acid changes: G272V, P301L and R406W. These mutations have been identified in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). |