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Allele : Trp73<tm1Mak> transformation related protein 73; targeted mutation 1, Tak Mak

Primary Identifier	MGI:3822523	Allele Type	Targeted
Attribute String	Modified isoform(s)	Gene	Trp73
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

Exons 2 and 3 were replaced with a floxed neo cassette. The absence of protein expression of all four TAp73 isoforms was confirmed by western blot analysis on ovary extracts. The deltaNp73 isoforms are expressed.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
TAp73<->,
TAp73<->

earliestPublication:
Tomasini R, et al. (2008) TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 22(19):2677-91

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

4 Carried By

0 Driven By

22 Publication categories

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