| First Author | Cui XB | Year | 2021 |
| Journal | Am J Physiol Endocrinol Metab | Volume | 320 |
| Issue | 1 | Pages | E131-E138 |
| PubMed ID | 33252250 | Mgi Jnum | J:302380 |
| Mgi Id | MGI:6508229 | Doi | 10.1152/ajpendo.00175.2020 |
| Citation | Cui XB, et al. (2021) ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice. Am J Physiol Endocrinol Metab 320(1):E131-E138 |
| abstractText | Obesity is an important independent risk factor for type 2 diabetes, cardiovascular diseases, and many other chronic diseases. The objective of this study was to determine the role of adenosine deaminase acting on RNA 1 (ADAR1) in the development of obesity and insulin resistance. Wild-type (WT) and heterozygous ADAR1-deficient (Adar1(+/-)) mice were fed normal chow or a high-fat diet (HFD) for 12 wk. Adar1(+/-) mice fed with HFD exhibited a lean phenotype with reduced fat mass compared with WT controls, although no difference was found under chow diet conditions. Blood biochemical analysis and insulin tolerance test showed that Adar1(+/-) improved HFD-induced dyslipidemia and insulin resistance. Metabolic studies showed that food intake was decreased in Adar1(+/-) mice compared with the WT mice under HFD conditions. Paired feeding studies further demonstrated that Adar1(+/-) protected mice from HFD-induced obesity through decreased food intake. Furthermore, Adar1(+/-) restored the increased ghrelin expression in the stomach and the decreased serum peptide YY levels under HFD conditions. These data indicate that ADAR1 may contribute to diet-induced obesity, at least partially, through modulating the ghrelin and peptide YY expression and secretion.NEW & NOTEWORTHY This study identifies adenosine deaminase acting on RNA 1 as a novel factor promoting high-fat diet-induced obesity, at least partially, through modulating appetite-related genes ghrelin and PYY. |
