| First Author | Lijnen HR | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 378 |
| Issue | 2 | Pages | 255-8 |
| PubMed ID | 19022221 | Mgi Jnum | J:143070 |
| Mgi Id | MGI:3822716 | Doi | 10.1016/j.bbrc.2008.11.032 |
| Citation | Lijnen HR, et al. (2009) Deficiency of vascular endothelial growth factor-D does not affect murine adipose tissue development. Biochem Biophys Res Commun 378(2):255-8 |
| abstractText | Vascular endothelial growth factor (VEGF)-D deficiency had no significant effect on total body weight or on subcutaneous (SC) or gonadal (GON) adipose tissue mass of mice kept on a standard fat (SFD) or a high fat diet (HFD) for 15 weeks. The composition of SC and GON adipose tissues of VEGF-D deficient mice in terms of size and density of adipocytes or blood vessels was also comparable to that of wild-type control mice. Staining of lymphatic vessels in adipose tissue sections did not reveal marked differences between both genotypes. The absence of an effect of VEGF-D deficiency could not be explained by compensatory increases of VEGF-C expression in adipose tissues of the deficient mice. Thus, our data do not support an important role of VEGF-D in (lymph) angiogenesis or in adipose tissue development. |
