| First Author | Tan SS | Year | 1993 |
| Journal | Nat Genet | Volume | 3 |
| Issue | 2 | Pages | 170-4 |
| PubMed ID | 8499950 | Mgi Jnum | J:3863 |
| Mgi Id | MGI:52369 | Doi | 10.1038/ng0293-170 |
| Citation | Tan SS, et al. (1993) X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo [published erratum appears in Nat Genet 1993 Jul;4(3):320]. Nat Genet 3(2):170-4 |
| abstractText | During mammalian development, one of the two X chromosomes in female embryos is randomly inactivated in the somatic cell in order to achieve gene dosage compensation. But is X inactivation established simultaneously or is it accomplished over time in a lineage-dependent fashion? We have examined this question in mouse embryos carrying an X-linked lacZ transgene. This transgene is subject to inactivation and the loss of beta-galactosidase activity provides a direct indication of X inactivation in individual cells. We find that X inactivation proceeds with different schedules in different somatic tissues, and the notochord, the heart, cranial mesoderm and the hindgut are among the last tissues to undergo X inactivation. |
