| First Author | Zeng X | Year | 2012 |
| Journal | Immunity | Volume | 37 |
| Issue | 3 | Pages | 524-34 |
| PubMed ID | 22960222 | Mgi Jnum | J:187670 |
| Mgi Id | MGI:5437771 | Doi | 10.1016/j.immuni.2012.06.011 |
| Citation | Zeng X, et al. (2012) gammadelta T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response. Immunity 37(3):524-34 |
| abstractText | gammadelta T cells contribute uniquely to immune competence. Nevertheless, how they function remains an enigma. It is unclear what most gammadelta T cells recognize, what is required for them to mount an immune response, and how the gammadelta T cell response is integrated into host immune defense. Here, we report that a noted B cell antigen, the algae protein phycoerythrin (PE), is a murine and human gammadelta T cell antigen. Employing this specificity, we demonstrated that antigen recognition activated naive gammadelta T cells to make interleukin-17 and respond to cytokine signals that perpetuate the response. High frequencies of antigen-specific gammadelta T cells in naive animals and their ability to mount effector response without extensive clonal expansion allow gammadelta T cells to initiate a swift, substantial response. These results underscore the adaptability of lymphocyte antigen receptors and suggest an antigen-driven rapid response in protective immunity prior to the maturation of classical adaptive immunity. |
